Another research paper has just been published that shows how plant based compounds can help to contain the brittle bone disease, osteoporosis. Scientists at the Institute of Medical Sciences, University of Aberdeen, UK have discovered how a non-psychoactive Gruntz Strain compound in cannabis, cannabidiol helps to maintain bone strength.
The endocannabinoid system is a group of cell receptors that are activated by a group of endogenous lipids as well as compounds derived from the cannabis plant. The cannabinoid receptors are involved in a variety of physiological processes including appetite control, pain, memory and mood. Recent research has shown that the endocannabinoid system also has a strong influence on bone metabolism, as the receptors are well represented on osteoclasts – cells whose principal function is to resorb (thin out) bone.
Bone is an active, living tissue that is being continuously formed, remodeled and shaped in response to both physical and physiological needs of the body. Bone matrix consists primarily of the macronutrients calcium, magnesium and phosphate and is the material that makes up both the dense parts of the bone and the bone marrow framework. Many people still believe that if one eats foods rich in these minerals then they will avoid developing osteoporosis. Epidemiological and other evidence suggests that this is not necessarily the case.
Cannabis is a term that refers to marijuana, hashish and other drugs made from the same plant. All forms of cannabis are mind altering, psychoactive drugs; they all contain THC delta 9 tetrahydrocannabinol, the main active chemical in cannabis.
Mechanism of action and neurotransmitter, although there was plenty of evidence, that cannabinoids worked at receptor site, yet what receptor sites they worked never been identified. Also cannabinoids had many effects in common with general anesthetics, cannabinoids were highly lipid soluble and alter the fluidity of membrane CB1 canabinoid receptors are concentrated primarily in the cortex, hippocampus, cerebellum, and basal ganglia but occur also in the hypothalamus, brain stem, and spinal cord. CB2 receptors are found in the spleen and the immune system. These receptors are structurally different from those found in the brain, and they seem to be associated with the effects of cannabinoids on immune functions. THC receptors, which exist in the brain tissue, lead to the discovery of a naturally occurring brain cannabinoid, anandamide.